Gena Rowlands

Ivy

Tony Shalhoub

Misha Vilyenkov

Cheech Marin

Ignacio

Bruce Davison

Dr. Reingold

Trini Alvarado

Adult Marie Alweather

Jay Mohr

Benny / Paulie (voice)

Buddy Hackett

Artie

Hallie Eisenberg

Marie Alweather

Matt Craven

Warren Alweather

Bill Cobbs

Virgil the Janitor

Tia Texada

Ruby / Lupe (voice)

Laura Harrington

Lila Alweather

Tamara Zook

Speech Therapist

Charles Parks

Gerald

Dig Wayne

Research Assistant #1

Michael Leydon Campbell

Research Assistant #2

Jerry Winsett

Mr. Tauper

Josh Cruze

Cantina Singer