Christopher Plummer

Sherlock Holmes

James Mason

Dr. Watson

David Hemmings

Inspector Foxborough

Susan Clark

Mary Kelly

Anthony Quayle

Sir Charles Warren

John Gielgud

Prime Minister

Frank Finlay

Inspector Lestrade

Donald Sutherland

Robert Lees

Geneviève Bujold

Annie Crook

Chris Wiggins

Dr. Hardy

Tedde Moore

Mrs. Lees

Peter Jonfield

William Slade

Roy Lansford

Sir Thomas Spivey

Ron Pember

Makins

Ken Jones

Dock Guard

June Brown

Annie Chapman

Ann Mitchell

Jane

Michael Cashman

Constable Watkins

Tony Clarkin

Police Sergeant (uncredited)

Jim McManus

Policeman (uncredited)