Basil Rathbone

Sherlock Holmes

Nigel Bruce

Dr. Watson

Ida Lupino

Ann Brandon

Alan Marshal

Jerrold Hunter

Terry Kilburn

Billy

George Zucco

Professor Moriarty

Henry Stephenson

Sir Ronald Ramsgate

E. E. Clive

Inspector Bristol

Arthur Hohl

Henchman Bassick

May Beatty

Mrs. Jameson, Brandon Housekeeper

Peter Willes

Lloyd Brandon

Mary Gordon

Mrs. Hudson

Holmes Herbert

Justice of the Court

George Regas

Henchman Mateo

Mary Forbes

Lady Conyngham

William Austin

Inquisitive Stranger

Leonard Mudie

Barrows - Moriarty's Attorney (uncredited)

Ivan F. Simpson

Gates - Trial Prosecutor (uncredited)

Frank Baker

Tompkins (uncredited)

Denis Greene

Denis Green (uncredited)

Leyland Hodgson

Bobby (uncredited)

Boyd Irwin

Bobby (uncredited)

Harry Cording

Second Fake Constable (uncredited)

Ted Billings

Pub Customer (uncredited)

Herbert Evans

Scotland Yard Man (uncredited)