Denzel Washington

Dr. Jerome Davenport

Derek Luke

Antwone Fisher

Malcolm David Kelley

Antwone Fisher Age 7

Viola Davis

Eva May

Joy Bryant

Cheryl Smolley

Salli Richardson-Whitfield

Berta Davenport

Leonard Earl Howze

Pork Chop

Kevin Connolly

Slim

Rainoldo Gooding

Grayson

Novella Nelson

Mrs. Tate

Stephen Snedden

Berkley

Sung Kang

Receptionist

Yolonda Ross

Nadine

James Brolin

The Captain (uncredited)

Jenifer Lewis

Aunt Mary Williams (uncredited)

Charles Robinson

Howard

Earl Billings

Uncle James

Vernee Watson-Johnson

Aunt Annette

De'Angelo Wilson

Jesse

Ellis Williams

Reverand Tate (as Ellis E. Williams)

Jascha Washington

Jesse - Age 8

Linda Cevallos

Sexy Woman

O.L. Duke

Uncle Duke

Lissy Gulick

Mona

Gary A. Jones

Relative (uncredited)