Matthew Broderick

Despereaux (voice)

Dustin Hoffman

Roscuro (voice)

Emma Watson

Princess Pea (voice)

Tracey Ullman

Miggery Sow (voice)

Kevin Kline

Chef Andre (voice)

Sigourney Weaver

The Narrator (voice)

William H. Macy

Lester (voice)

Stanley Tucci

Boldo (voice)

Ciarán Hinds

Botticelli (voice)

Robbie Coltrane

Gregory (voice)

Tony Hale

Furlough (voice)

Frances Conroy

Antoinette (voice)

Frank Langella

Mayor (voice)

Richard Jenkins

Principal (voice)

Christopher Lloyd

Hovis (voice)

Charles Shaughnessy

Pietro (voice)

McNally Sagal

Teacher (voice)

Sam Fell

Ned / Smudge (voice)