John Travolta

James

Kirstie Alley

Mollie

Olympia Dukakis

Rosie

Elias Koteas

Stuart

Twink Caplan

Rona

Bruce Willis

Mikey (voice)

Roseanne Barr

Julie (voice)

Damon Wayans

Eddie (voice)

Gilbert Gottfried

Joey

Mel Brooks

Mr. Toilet Man (voice)

Neal Israel

Mr. Ross

Lesley Ewen

Debbie

Noelle Parker

Woman Client

Douglas Warhit

Man Client

Terry David Mulligan

IRS Inspector

Paul Shaffer

Taxi Businessman

Don S. Davis

Dr. Fleischer

Morris Panych

Arrogant Businessman

Alex Bruhanski

Needle Doctor

Heather Lea Gerdes

Hot Babe on Fire Escape

Rick Avery

Burglar

Stephen Dimopoulos

Fire Chief

Jimmy Galeota

Punk Baby

Mollie Heckerling

Mikey's Dream Friend

Denis Corbett

Cop (uncredited)

Yolanda Corbett

Shopper (uncredited)