Meg Ryan

Kathleen Kelly

Tom Hanks

Joe Fox

Greg Kinnear

Frank Navasky

Heather Burns

Christina Plutzker

Parker Posey

Patricia Eden

Dave Chappelle

Kevin Jackson

Jean Stapleton

Birdie Conrad

Steve Zahn

George Pappas

Dabney Coleman

Nelson Fox

John Randolph

Schulyer Fox

Hallee Hirsh

Annabelle Fox

Jeffrey Scaperrotta

Matt Fox

Cara Seymour

Gillian Quinn

Katie Finneran

Maureen, the Nanny

Michael Badalucco

Charlie

Deborah Rush

Veronica Cash

Veanne Cox

Miranda Margulies

Bruce Jay Friedman

Vince Mancini

Sara Ramirez

Rose, Zabars Cashier

Diane Sokolow

Zabars Shopper

Reiko Aylesworth

Thanksgiving Guest

Katie Sagona

Young Kathleen Kelly

Kathryn Meisle

Cecilia Kelly

Julie Galdieri

Shopper

Mary A. Kelly

Fox Books Shopper

Chris Messina

Fox Salesperson

Ronobir Lahiri

Man at Cafe Lalo

André Sogliuzzo

Waiter at Lalo

Bill McHugh

Party Guest

Jane Adams

Sydney Anne (uncredited)

Cecelia Antoinette

Restaurant Patron (uncredited)

Alfonso Gomez-Rejon

Party Guest (uncredited)

Gideon Jacobs

Young Joe Fox (uncredited)