Whoopi Goldberg

Jane Deluca

Mary-Louise Parker

Robin

Drew Barrymore

Holly Pulchik-Lincoln

Matthew McConaughey

Abe Lincoln

James Remar

Alex

Billy Wirth

Nick

Anita Gillette

Elaine

Dennis Boutsikaris

Massarelli

Estelle Parsons

Louise

Amy Aquino

Anna

Stan Egi

Henry

Stephen Gevedon

Johnny Figgis/Jane's Band

Amy Ray

Indigo Girl

Emily Saliers

Indigo Girl

Jude Ciccolella

Jerry

Gedde Watanabe

Steve

Jon Seda

Pete

Lori Alan

Girl with Attitude

Mary Anne McGarry

Dr. Newbauer

Niecy Nash-Betts

Woman at Diner

Marnie Crossen

Nurse

Aaron Lustig

Judge

Pablo Espinosa

New Mexico Police

Don Hewitt Sr.

Tow Truck Driver

Tito Larriva

Indigo Girls' Band

Joseph Alfieri

Bartender (voice)