Aaron Eckhart

Dr. Josh Keyes

Hilary Swank

Maj. Rebecca Childs

Delroy Lindo

Dr. Ed 'Braz' Brazzleton

Stanley Tucci

Dr. Conrad Zimsky

Tchéky Karyo

Serge

DJ Qualls

Theodore Donald 'Rat' Finch

Richard Jenkins

Gen. Thomas Purcell

Bruce Greenwood

Cmdr. Robert Iverson

Christopher Shyer

Dave Perry

Ray Galletti

Paul

Eileen Pedde

Lynne

Rekha Sharma

Danni

Tom Scholte

Acker

Glenn Morshower

FBI Agent

Anthony Harrison

FBI Agent

Alfre Woodard

Stickley

Fred Keating

Court-Martial Presiding Officer

Bart Anderson

Dad

Nicole Leroux

Mom

Chris Humphreys

GBTV Reporter - Trafalgar Square

Dion Johnstone

Flight Engineer Timmins

Fred Ewanuick

Endeavor Flight Engineer

Hrothgar Mathews

Chief Engineer Mission Control

Jennifer Spence

Zimsky's Assistant

Michael St. John Smith

Pentagon General

John Shaw

FBI Agent - Rat's Apartment

Nickolas Baric

Security Policeman - Tribunal

Rosa Di Brigida

Rome Café Patron

Ermanno De Biagi

Rome Café Patron

Matt Winston

Luke Barry

Claire Riley

News Anchor

Laurie Murdoch

Project Destiny Engineer

Lenie Scoffié

Paris Café Lady

Nathaniel DeVeaux

U.S.S. Constellation Captain

Alec Medlock

(voice) (uncredited)

Alonso Oyarzun

Security Policeman (uncredited)

Rick Kain

Chief Petty Officer (uncredited)

Pamela Martin

News Anchor (uncredited)