Reese Witherspoon

Dr. Elizabeth Masterson

Mark Ruffalo

David Abbott

Donal Logue

Jack Houriskey

Dina Spybey-Waters

Abby Brody

Ben Shenkman

Dr. Brett Rushton

Jon Heder

Darryl

Ivana Miličević

Katrina

Caroline Aaron

Grace

Rosalind Chao

Fran

Ron Canada

Dr. Walsh

Willie Garson

Maitre D'

Kerris Dorsey

Zoe

Alyssa Shafer

Lily

Gabrielle Made

Nurse Maria

Shulie Cowen

Nurse Jenny

Billy Beck

Mr. Clarke

Catherine Taber

Intern Karen

Chris Pflueger

Abby's Husband

Paul Cassell

Brett's Friend

Raymond O'Connor

Catholic Priest

Lucille Soong

Chinese Exorcist

Joel McKinnon Miller

Lead Ghostbuster

Victor Yerrid

Ghostbuster

Bobby Benjamin

Ghostbuster

Lorna Scott

Hippie Neighbour

Jeffrey Marcus

Uptight Neighbour

Ken Takemoto

Chinese Neighbour

Chaim Jeraffi

Dry Cleaner

Lee Burns

Ivan the Bartender

Tim Connolly

Security Guard

Tim Sitarz

Security Guard

Tony Brubaker

Security Guard

Jimmy Ortega

Security Guard

Yeena Fisher

Seamstress (uncredited)