Geena Davis

Angie Scacciapensieri

Stephen Rea

Noel Riordan

James Gandolfini

Vinnie

Aida Turturro

Tina

Philip Bosco

Frank Scacciapensieri

Jenny O'Hara

Kathy

Michael Rispoli

Jerry

Betty Miller

Joanne

Ray Xifo

Dr. Gould

Rae Allen

Aunt Violetta

Frank Pellegrino

Uncle Marty

Michael Laskin

Surgeon

Elaine Kagan

Aunt Jean

Olga Merediz

Roz

Marylouise Burke

Fern

Marin Hinkle

Young Joanne

Nancy Giles

Bedside Nurse

Charlayne Woodard

Floor Nurse

Adam LeFevre

Museum Guard

Michael Goldfinger

Director

Joanne Baron

ICU Nurse #1

April Grace

ICU Nurse #2

Vernee Watson-Johnson

ICU Desk Nurse

Bibi Osterwald

Dr. Gould's Nurse

Joanna Sanchez

Admissions Nurse #1

Margaret Cho

Admissions Nurse #2

John Toles-Bey

Hospital Guard

Eileen Davies

Cranky Labor Nurse

Tony Ray Rossi

Mechanic #2

Lena Banks

Art Museum Patron (uncredited)