Isabella Rossellini

Dorothy Vallens

Kyle MacLachlan

Jeffrey Beaumont

Dennis Hopper

Frank Booth

Laura Dern

Sandy Williams

Hope Lange

Mrs. Williams

Dean Stockwell

Ben

George Dickerson

Detective Williams

Priscilla Pointer

Mrs. Beaumont

Frances Bay

Aunt Barbara

Ken Stovitz

Mike

Brad Dourif

Raymond

Jack Nance

Paul

J. Michael Hunter

Hunter

Selden Smith

Nurse Cindy

Angelo Badalamenti

Piano Player