Alec Baldwin

Theodore Templeton (voice)

James Marsden

Tim Templeton (voice)

Amy Sedaris

Tina Templeton (voice)

Ariana Greenblatt

Tabitha Templeton (voice)

Jeff Goldblum

Dr. Armstrong (voice)

Eva Longoria

Carol Templeton (voice)

James McGrath

Wizzie (voice)

Jimmy Kimmel

Ted Templeton (voice)

Lisa Kudrow

Janice Templeton (voice)

Raphael Alejandro

Nathan / Lead Baby Ninja (voice)

David Soren

Jimbo (voice)

James Ryan

Story Bear (Connie) (voice)

David P. Smith

Movie Patron (voice)

Tom McGrath

Dr. Tiffany Hamilton (voice)

Reyn Doi

Box Kid (voice)

Walt Dohrn

Baby Bouncer (voice)

Miles Bakshi

Young Tim Voice-Over (voice)