Dudley Moore

Dr. Jack Hammond / Chris Hammond

Kirk Cameron

Chris Hammond / Dr. Jack Hammond

Margaret Colin

Ginnie Armbruster

Catherine Hicks

Dr. Amy Larkin

Patrick O'Neal

Dr. Larry Armbruster

Sean Astin

Clarence / Trigger

Camille Cooper

Lori Beaumont

Micah Grant

Rick Anderson, Lori's Boyfriend

Skeeter Vaughan

Medicine Man

Larry Sellers

Navajo Helper

Maxine Stuart

Phyllis, Hammonds' Housekeeper

David Wohl

Dr. Roger Hartwood

Michael Horton

Dr. Mike O'Donald

Randy Lowell

Dr. Spellner

Christine Healy

Hospital Administrator

Brian Peck

Intern with Heart Patient

Carol Swarbrick

Norma, Hospital Secretary

Dakin Matthews

Old Man Morrison

Les Lannom

Coach Ellis

Bill Stevenson

Biology Student

Alexandra Kenworthy

Janice Stenfield, College Interviewer

Lloyd Nelson

Teacher in Hall

Armin Shimerman

Trigger's Dad

Kitty Swink

Trigger's Mom

James Lashly

Freemont, Corky's Man

Nancy Lenehan

Waitress in Desert Diner