Adrien Brody

Psycho Ed

Matt Bush

Henry Burke

Sean Marquette

Travis Breaux

Colin Hanks

Brandon Ellis

Michael Chiklis

Dr. Leslie Gordon

Adhir Kalyan

Sebastian Saleem

Mykelti Williamson

Paranoid

Luis Chávez

Big Dave

Max Van Ville

Little Dave

Brett Kelly

Martin Gordon

George Back

Malcolm

Alicia Sixtos

Sharky Ovante

Andrew Wilson

Hippie Dude

Camille Mana

Dana

Erica Vittina Phillips

Tameka

Julia Ling

Charlyne

Cody Longo

Chad

Mary Birdsong

Mrs. Gordon

Yeardley Smith

Computer Skills Teacher

Curtis Armstrong

Mr. Thompson

Barret Swatek

Female News Desk Reporter

Rhys Coiro

Vato

Wyatt Russell

Drug PSA Stoned Teenager

Robert Bailey Jr.

Jeffrey

Wallace Bridges

African American Donor

Linda Boston

Head Nurse

Nadine Crocker

Emily Tooms

Rachel Quaintance

Angry Parent #1

Peter Tocco

Angry Parent #2

Sammy A. Publes

Cook #1

J. J. Soria

Rubin

John O'Hurley

Drug PSA (voice)

Michael Vartan

Calculus Teacher (uncredited)

Amanda Bright

High School Student (uncredited)