Brendan Fraser

Stu Miley

Bridget Fonda

Dr. Julie McElroy

John Turturro

Monkeybone (voice)

Chris Kattan

Organ Donor Stu

Giancarlo Esposito

Hypnos

Rose McGowan

Miss Kitty

Dave Foley

Herb

Megan Mullally

Kimmy Miley

Bob Odenkirk

Head Surgeon

Whoopi Goldberg

Death

Pat Kilbane

Burger God Representative

Lisa Zane

Medusa

Sandra Thigpen

Alice

Wayne Wilderson

Hutch

Amy Higgins

Clarissa

Alan Gelfant

Dr. Edelstein

Kristin Norton

Nurse

Chris Hogan

Bill, Bazoom Toy Representative

Lucy Butler

Guest

Lou Romano

Cop / Psycharist

Scott Rogers

Surgeon

Ted Rooney

Grim Reaper (voice)

Mary Stein

Lulu

Kristopher Logan

Patron

Scott Workman

Arnold the Super Reaper

Shawnee Free Jones

Lizzie Borden

Ilia Volok

Rasputin

Claudette Mink

Typhoid Mary

Jon Bruno

Man in the Dungeon / Stephen King

Owen Masterson

Jack the Ripper

Jen Sung

Attila the Hun

Tracy Zahoryin

Model

Rex Reddick

Museum Guard / Tuxedo Guard

Sybil Azur

Museum Dancer

Anne Fletcher

Museum Dancer

Diane Mizota

Museum Dancer

Frankie Pine

All-Girl Band Member

Veena Bidasha

Statue Woman

Doug Jones

Yeti

Arturo Gil

Rat Guard

Brian Steele

Jumbo the Elephant God

Leif Tilden

Cyclops

Joseph S. Griffo

BBQ Pig

Joe Ranft

Streetsquash Rabbit (voice)

Bruce Lanoil

Streetsquash Raccoon (voice)

Debi Durst

Streetsquash Snake (voice)

Roger L. Jackson

Arnold the Super Reaper (voice)

Allan Trautman

BBQ Pig (voice)

Mike Mitchell

Miss Hudiapp (voice)

Randall Bosley

Fred

Thomas Haden Church

Death's Assistant

Jamie Donovan

Reporter #1

Wendy Fowler

Beautiful Fan

Jason Kravits

Guest