Klaus Kinski

Don Lope de Aguirre

Helena Rojo

Inés de Atienza

Del Negro

Brother Gaspar de Carvajal

Ruy Guerra

Don Pedro de Ursúa

Peter Berling

Don Fernando de Guzmán

Daniel Ades

Perucho

Edward Roland

Okello

Claus Biederstaedt

Brother Gaspar de Carvajal (voice) (uncredited)

Christian Brückner

Balthasar (voice) (uncredited)

Manfred Lehmann

Conqueror (voice) (uncredited)