Quvenzhané Wallis

Annie Bennett

Jamie Foxx

William "Will" Stacks

Rose Byrne

Grace Farell

Cameron Diaz

Miss Colleen Hannigan

Bobby Cannavale

Guy

Adewale Akinnuoye-Agbaje

Nash

David Zayas

Lou

Amanda Troya

Pepper

Zoe Colletti

Tessie

Nicolette Pierini

Mia

Eden Duncan-Smith

Isabella

Dorian Missick

Annie's "Dad"

Tracie Thoms

Annie's "Mom"

Mike Birbiglia

Social Services Inspector

Stephanie Kurtzuba

Mrs. Kovacevic

Peter Van Wagner

Harold Gray

Michael J. Fox

Himself

Raushanah Simmons

YaYa L'Occitane

DonnaMarie Recco

Woman on Street

Mila Kunis

Andrea Alvin

Ashton Kutcher

Simon Goodspeed

Rihanna

Moon Goddess

Patricia Clarkson

Focus Group Woman

Sia

Animal Care & Control Volunteer

Bobby Moynihan

Guy In Bar

Pat Kiernan

NY1 Reporter

Andrew Fleming

Cleve Sweetzer

Ray Iannicelli

Waiter at Domani

Ty Jones

Stacks Mobile Reporter

Victor Cruz

Teacher

Taylor Richardson

Red Haired "Annie"

Derrick Baskin

Auditioning 'Dad'

Pernell Walker

Auditioning 'Mom'

J. Kaitlin Becker

Grace's Assistant

Ruby Rose Turner

Orphan #8 (uncredited)

Maesi Caes

Orphan #3 (uncredited)

Josh Elliott Pickel

(uncredited)

Lily Peterson

Tessie Photo Double

Patricia Pinto

Mom

Alan D. Purwin

Stacks' Pilot

Nicholas Pinto

Friend of foster girls

Amyrh Harris

Classroom Kid

Gabriella Baldacchino

Classmate (uncredited)

Tate McRae

Orphan #17 (uncredited)

Booch O'Connell

Movie Premiere Guest (uncredited)