Basil Rathbone

Sherlock Holmes

Nigel Bruce

Doctor Watson

Lionel Atwill

Professor Moriarty

William Post Jr.

Dr. Franz Tobel

Kaaren Verne

Charlotte Eberli

Dennis Hoey

Inspector Lestrade

Holmes Herbert

Sir Reginald

Mary Gordon

Mrs. Hudson

Harry Cording

Jack Brady (uncredited)

Paul Fix

Mueller (uncredited)

Henry Victor

Professor Frederic Hoffner (uncredited)

Paul Bryar

Swiss Waiter (uncredited)

Whit Bissell

London Bobbie (uncredited)

Rudolph Anders

Braun (uncredited)

Colin Kenny

Scotland Yard Detective (uncredited)

Harry Woods

Kurt (uncredited)