Owen Wilson

Reggie (voice)

Woody Harrelson

Jake (voice)

Amy Poehler

Jenny (voice)

George Takei

S.T.E.V.E. (voice)

Colm Meaney

Myles Standish (voice)

Keith David

Chief Broadbeak (Voice)

Dan Fogler

Governor William Bradford (voice)

Jimmy Hayward

Ranger / Leatherbeak / President / Hazmats (voice)

Danny Carey

Danny (voice)

Carlos Ponce

Narrator / Alejandro (voice)

Robert Beltran

Chief Massasoit (voice)

Lesley Nicol

Female Pilgrim (voice)

Kaitlyn Maher

President's Daughter (voice)

Carlos Alazraqui

Amos (voice)

Josh Lawson

Gus (Voice)

Scott Mosier

Pizza Dude (voice)

Lauren Bowles

Jake's Mother (voice)

Dwight Howard

Cold Turkey (Voice)

Vincente DiSanti

(voice)

David S. Lee

(voice)

Alina Phelan

(voice)

William Morgan Sheppard

(voice)