Tobey Maguire

Homer Wells

Charlize Theron

Candy Kendall

Delroy Lindo

Arthur Rose

Paul Rudd

Lt. Wally Worthington

Michael Caine

Dr. Wilbur Larch

Jane Alexander

Nurse Edna

Kathy Baker

Nurse Angela

Erykah Badu

Rose Rose

Kieran Culkin

Buster

Kate Nelligan

Olive Worthington

Heavy D

Peaches

J.K. Simmons

Ray Kendall

Erik Per Sullivan

Fuzzy

Paz de la Huerta

Mary Agnes

K. Todd Freeman

Muddy

Evan Parke

Jack

Lonnie Farmer

Hero

Skye McCole Bartusiak

Hazel

Annie Corley

Carla

Patrick Donnelly

Adopting Father

John Irving

Stationmaster

Eric Bruno Borgman

Flirting Soldier on Train (uncredited)

Kevin Chapman

Adopting Dad (uncredited)

John H. Tobin

Man on Train (uncredited)