Reese Witherspoon

Susan Murphy / Ginormica (voice)

Seth Rogen

B.O.B. (voice)

Hugh Laurie

Dr. Cockroach Ph.D. (voice)

Rainn Wilson

Gallaxhar (voice)

Will Arnett

The Missing Link (voice)

Kiefer Sutherland

General W.R. Monger (voice)

Paul Rudd

Derek Dietl (voice)

Stephen Colbert

President Hathaway (voice)

Julie White

Wendy Murphy (voice)

Jeffrey Tambor

Carl Murphy (voice)

Amy Poehler

Computer (voice)

Ed Helms

News Reporter (voice)

Renée Zellweger

Katie (voice)

Rob Letterman

Secret Service Man #1 / Lieutenant (voice)

Tom McGrath

Wilson (voice)

Chris Miller

Advisor Cole / Army Commander Jones (voice)

Mike Mitchell

Advisor Wedgie (voice)

Kent Osborne

Technician Jerry (voice)

Latifa Ouaou

Advisor Ouaou / Mrs. Ronson / Female Advisor #2 / Panicked Guest (voice)

Geoffrey Pomeroy

Soldier #4 / Pilot / Soldier #3 / News Technician (voice)

David P. Smith

Soldier #1 / Advisor Jackson (voice)

Conrad Vernon

Advisor Hawk / Advisor Dither / Minister / Secret Service Man #2 / Mama Dietl (voice)

John Krasinski

Cuthbert (voice)

Stephen Kearin

Technician Bee (voice)