Antonio Banderas

El Mariachi

Johnny Depp

CIA Agent Jeffrey Sands

Cheech Marin

Belini

Salma Hayek Pinault

Carolina

Mickey Rourke

Billy Chambers

Willem Dafoe

Armando Barillo

Eva Mendes

CIA Agent Ajedrez

Danny Trejo

Cucuy

Rubén Blades

Jorge, Retired FBI Agent

Enrique Iglesias

Lorenzo

Marco Leonardi

Fideo

Troy Robinson

Romero

Pedro Armendáriz Jr.

President of Mexico

Julio Oscar Mechoso

Nicholas, Presidential Advisor

Tito Larriva

Cab Driver

Ignacio Torre

Teacher

Rojo Grau

Manny

Dagoberto Gama

Que Pasa

Thomas Rosales Jr.

Bartender with Gun (uncredited)

Khristian Lupo

Soldier (uncredited)