Jake Gyllenhaal

Donnie Darko

Jena Malone

Gretchen Ross

James Duval

Frank

Drew Barrymore

Karen Pomeroy

Beth Grant

Kitty Farmer

Maggie Gyllenhaal

Elizabeth Darko

Mary McDonnell

Rose Darko

Holmes Osborne

Eddie Darko

Noah Wyle

Prof. Kenneth Monnitoff

Katharine Ross

Dr. Lilian Thurman

Patrick Swayze

Jim Cunningham

Daveigh Chase

Samantha Darko

Arthur Taxier

Dr. Fisher

David St. James

Bob Garland

Patience Cleveland

Roberta Sparrow / Grandma Death

Jolene Purdy

Cherita Chen

David Moreland

Principal Cole

Kristina Malota

Susie Bates

Scotty Leavenworth

David

Phyllis Lyons

Anne Fisher

Alex Greenwald

Seth Devlin

Stuart Stone

Ronald Fisher

Joan Blair

Mystery Woman

Seth Rogen

Ricky Danforth

Jerry Trainor

Lanky Kid

Lisa K. Wyatt

Linda Connie

Rachel Winfree

Shanda Riesman

Ashley French

Kim

Tiler Peck

Beth Farmer

Fran Kranz

Passenger

Sarah Hudson

Friend

Lee Weaver

Leroy

Jack Salvatore, Jr.

Larry Riesman

Nancy Juvonen

Flight Attendant (uncredited)