Tim Roth

Stretch

Tupac Shakur

Spoon

Thandiwe Newton

Cookie

Charles Fleischer

Mr. Woodson

Vondie Curtis-Hall

D-Reper

Howard Hesseman

Blind Man

James Pickens Jr.

Supervisor

Tom Towles

D-Reper's Henchman

Bokeem Woodbine

Mud (uncredited)

John Sayles

Cop #1

Eric Payne

Cop #2

Tom Wright

Koolaid

Mik Scriba

Officer #1

Lucy Liu

Cee-cee

Richmond Arquette

Resident Doctor

Billie Neal

Medicaid Woman #1

Debra Wilson

Medicaid Woman #2

Rusty Schwimmer

Nurse

Elizabeth Peña

Admissions Person

Darryl Jones

Panhandler

Venessia Valentino

Woman in ER

Ron Cummins

Man in ER

Tracy Vilar

Screaming Woman

Lynn Blades

Alexia Cruz

Kasi Lemmons

Madonna

Henry Hunter Hall

Child