Danny DeVito

Owen Lift

Billy Crystal

Larry Donner

Kim Greist

Beth Ryan

Anne Ramsey

Mrs. Lift

Kate Mulgrew

Margaret Donner

Branford Marsalis

Lester

Rob Reiner

Joel

Bruce Kirby

Detective DeBenedetto

Annie Ross

Mrs. Hazeltine

Raye Birk

Pinsky

Oprah Winfrey

Herself

Olivia Brown

Ms. Gladstone

J. Alan Thomas

Millington

Randall Miller

Bucky

Andre Rosey Brown

Rosey

Tony Ciccone

Mr. Lopez

Larry McCormick

Announcer

Peter Brocco

Old Man