Donald Sutherland

Matthew Bennell

Brooke Adams

Elizabeth Driscoll

Leonard Nimoy

Dr. David Kibner

Jeff Goldblum

Jack Bellicec

Veronica Cartwright

Nancy Bellicec

Art Hindle

Dr. Geoffrey Howell

Lelia Goldoni

Katherine Hendley

Kevin McCarthy

Running Man

Don Siegel

Taxi Driver

Tom Luddy

Ted Hendley

Stan Ritchie

Stan

Tom Dahlgren

Detective

Garry Goodrow

Dr. Boccardo

Jerry Walter

Restaurant Owner

Maurice Argent

Chef

Wood Moy

Mr. Tong

Joe Bellan

Harry

Al Nalbandian

Rodent Man

Robert Duvall

Priest on Swing (uncredited)

Michael Chapman

Health Dept. Floor Cleaner (uncredited)

Philip Kaufman

City Official on Phone (uncredited) (voice)