Glenn Close

Cruella de Vil

Gérard Depardieu

Jean Pierre Le Pelt

Ioan Gruffudd

Kevin Shepherd

Alice Evans

Chloe Simon

Tim McInnerny

Alonzo

Eric Idle

Waddlesworth (voice)

Ben Crompton

Ewan

Carol MacReady

Agnes

Ian Richardson

Mr. Torte

Jim Carter

Detective Armstrong

Ron Cook

Mr. Button

Timothy West

Judge

David Horovitch

Dr. Pavlov

Mike Hayley

Constable

Nicholas Hutchison

Reporter

June Watson

Prison Warden

Tony Bluto

Photocopier Repairman

Tessa Vale

Ticket Seller

Kerry Shale

Le Pelt's Assistant

Dorothea Phillips

Mrs. Mirthless

JB Blanc

Police Captain (uncredited)

Greg Bronson

Luncheon Attendee (uncredited)

Rene Costa

Paparazzi (uncredited)

David Keyes

Waddlesworth (voice; uncredited)

Tina Simmons

Fashionista (uncredited)