Denzel Washington

Lincoln Rhyme

Angelina Jolie

Amelia Donaghy

Queen Latifah

Thelma

Michael Rooker

Captain Howard Cheney

Michael McGlone

Detective Kenny Solomon

Luis Guzmán

Eddie Ortiz

Leland Orser

Richard Thompson

John Benjamin Hickey

Dr. Barry Lehman

Bobby Cannavale

Steve, Amelia's Boyfriend

Ed O'Neill

Detective Paulie Sellitto

Richard Zeman

Lieutenant Carl Hanson

Olivia Birkelund

Lindsay Rubin

Gary Swanson

Alan Rubin

Frank Fontaine

Grandfather

Zena Grey

Granddaughter

Desmond Campbell

Taxi Inspector

Peter Michael Dillon

Homicide Detective

Ted Whittall

Ortiz's Assistant

Steve Adams

Gas Worker

Larry Day

Gas Worker

Terry Simpson

Cop in Apartment

Eric Davis

Cop in Apartment

Arthur Holden

Bookstore Clerk

Yahsmin Daviault

Rhyme's Sister

David Warshofsky

Amelia's Partner

Mateo Gómez

Hot Dog Vendor

Fulvio Cecere

Forensics Expert

Russell Yuen

Forensics Worker