Meg Ryan

Jackie Kallen

Omar Epps

Luther Shaw

Charles S. Dutton

Felix Reynolds

Tony Shalhoub

Sam LaRocca

Tim Daly

Gavin Reese

Joe Cortese

Irving Abel

Kerry Washington

Renee

Sean Bell

Ray Kallen

Dean McDermott

Pete Kallen

Skye McCole Bartusiak

Little Jackie

Juan Carlos Hernández

Pedro Hernandez

Holt McCallany

Dorsett

Tory Kittles

Devon Green

Beau Starr

Corcoran

Diego Fuentes

Car Attendant

Angelo Tucci

Rex

Merwin Mondesir

Street Crony

Doug Lennox

Barrel-Chested Man

Moses Nyarko

Mouketendi ("Africa")

Aidan Devine

Crisco

Joel Harris

Mathias

Bruce Gooch

Pawn Shop Clerk

Arnold Pinnock

Heavyweight

Neven Pajkic

Heavyweight

Dov Tiefenbach

Organic Clerk

Mike Kraft

Jacobs

Tamara Hickey

Megan the Reporter

Karen Robinson

Kimberly (Insurance)

Noah Dalton Danby

LaRocca Henchman

Tracy Waterhouse

Receptionist

Michael Buffer

Ring Announcer

Neil Crone

HBO Commentator

Jean Daigle

Montage Promoter

Jason Jones

Ticket Guy

Shawn Lawrence

Philadelphia Fight Official

Nick Alachiotis

Luther's Trainer

Syd Vanderpool

Luther's Tampa Opponent

Egerton Marcus

Hopeful Fighter

Rogue Johnston

Montage Opponent (ss Rogue Johnson)