Stephen Fry

Leonardo da Vinci (voice)

Daisy Ridley

Princess Marguerite (voice)

Marion Cotillard

Louise de Savoy (voice)

Matt Berry

Pope Leo XI (voice)

Natalie Palamides

Pierre Nepveu / Antonio de Beatis (voice)

Jim Capobianco

Cardinal of Aragon (voice)

Gauthier Battoue

Francis I of France (voice)

John Gilkey

Gravedigger John / Giuliano (voice)