Ewan McGregor

Ed Bloom (young)

Albert Finney

Ed Bloom (senior)

Billy Crudup

Will Bloom

Jessica Lange

Sandra Bloom (senior)

Helena Bonham Carter

Jenny (young & senior) / The Witch

Alison Lohman

Sandra Bloom (young)

Robert Guillaume

Dr. Bennett (senior)

Marion Cotillard

Josephine

Matthew McGrory

Karl the Giant

David Denman

Don Price (age 18-22)

Missi Pyle

Mildred

Loudon Wainwright III

Beamen

Ada Tai

Ping

Arlene Tai

Jing

Steve Buscemi

Norther Winslow

Danny DeVito

Amos Calloway

Deep Roy

Mr. Soggybottom

Hailey Anne Nelson

Jenny (age 8)

R. Keith Harris

Ed's Father

Karla Droege

Ed's Mother

John Lowell

Don Price (age 12)

Darrell Vanterpool

Wilbur (age 10)

Miley Cyrus

Ruthie (age 8)

Morgan Grace Jarrett

Will's Date

Frank Hoyt Taylor

Sharecropper

Billy Redden

Banjo Man

James DeForest Parker

Shotgun Toter

Russell Hodgkinson

Some Farmer

Zach Hanner

Cashier

Lawrence Sykkmon

Chinese Emcee

Bonnie Johnson

Teller Woman

Trevor Gagnon

Will's son

Bevin Kaye

River Woman

L.C. Holt

Spectre Citizen (uncredited)