Paul Reubens

Pee-wee Herman

E. G. Daily

Dottie

Mark Holton

Francis

Diane Salinger

Simone

Judd Omen

Mickey

Irving Hellman

Mr. Crowtrey

Monte Landis

Mario

Damon Martin

Chip

Alice Nunn

Large Marge

David C. Glasser

BMX Kid

Gregory Brown

BMX Kid

Daryl Keith Roach

Chuck

Bill Cable

Policeman #1

Peter Looney

Policeman #2

Starletta DuPois

Sgt. Hunter

Ed Herlihy

Mr. Buxton

Ralph Seymour

Francis' Accomplice

Lou Cutell

Amazing Larry

Raymond Martino

Gang Member

Erica Yohn

Madam Ruby

Simmy Bow

Man in Diner

Jon Harris

Andy

Carmen Filpi

Hobo Jack

Jan Hooks

Tina

Luis Contreras

Biker #2

Cassandra Peterson

Biker Mama

Jason Hervey

Kevin Morton

John Paragon

Movie Lot Actor

Susan Barnes

Movie Lot Actress

Lynne Marie Stewart

Mother Superior

Richard Brose

Tarzan

Phil Hartman

Reporter

Patrick Cranshaw

Hobo

Sunshine Parker

Hobo

James Brolin

"P. W."

Morgan Fairchild

"Dottie"

Tony Bill

Terry Hawthorne

Milton Berle

Self (uncredited)

Tim Burton

Thug in Alley (uncredited)