Seth Rogen

B.O.B. (voice)

Reese Witherspoon

Susan Murphy / Ginormica (voice)

Hugh Laurie

Dr. Cockroach Ph.D. (voice)

Will Arnett

The Missing Link (voice)

Kiefer Sutherland

General W.R. Monger (voice)

Rainn Wilson

Wicked Jack (voice)

Jeffrey Tambor

Carl Murphy (voice)

Julie White

Wendy Murphy (voice)

Walt Dohrn

Link Kid (voice)

Latifa Ouaou

Boy / Old Lady (voice)

Peter Ramsey

Dad / Farmer Jeb (voice)

Conrad Vernon

Man on Cell / Woman (voice)