Ray Romano

Manny (voice)

John Leguizamo

Sid (voice)

Denis Leary

Diego (voice)

Goran Višnjić

Soto (voice)

Jack Black

Zeke (voice)

Cedric the Entertainer

Carl (voice)

Stephen Root

Frank / Start (voice)

Diedrich Bader

Oscar (voice)

Alan Tudyk

Lenny / Freaky Mammal / Dab (voice)

Lorri Bagley

Jennifer (voice)

Jane Krakowski

Rachel (voice)

Josh Hamilton

Dodo / Aardvark (voice)

Chris Wedge

Dodo / Scrat (voice)

Denny Dillon

Glyptodon (voice)

Mitzi McCall

Glyptodon (voice)

Tara Strong

Baby Start (voice)

Darin De Paul

Additional Voices (voice) (uncredited)

Dann Fink

Dodo (voice) (uncredited)

Phil Proctor

Various Mammals (uncredited)