Kate Hudson

Skye Davidson

Brendan Sexton III

Blue Baxter

John Heard

Prof. Lance Davidson

Christina Ricci

Ely Jackson

Casey Affleck

Pete Kepler

Sara Gilbert

Sandy

Ethan Suplee

Cale

Peter Sarsgaard

Billy Baxter

Lucinda Jenney

Caroline Baxter

Michael Ironside

Agent Frank Bellows

Daniel von Bargen

Sheriff Jackson

Aunjanue Ellis-Taylor

Agent Summers

Isidra Vega

Haley Gordon

Rene Rivera

Dr. Gordon

Liev Schreiber

Mickey Moonday (voice)

Richmond Arquette

Truck Driver

Ntare Guma Mbaho Mwine

Agent Green