Susan Sarandon

Rose Collins

Paul Walker

Mike Riley

Penélope Cruz

Nina Vasquez

Alan Arkin

Artie

Marcus Thomas

Jules Calvert

Sonny Marinelli

Dennis

Daniel Sunjata

Marco

Chazz Palminteri

Arizona

Robin Williams

Charlie Boyd / The Priest

Rob Daly

Paul

John Doman

Dr. Baron

Billy Porter

Randy

Carmen Ejogo

Dr. Batiste

Donna Hanover

Debbie Carmichael

Merwin Mondesir

Glenn

Una Kay

Helen

Sonia Benezra

Aunt Sonya

Marcia Bennett

Nurse Stein

Howard Rosenstein

ER Doctor

Jane Wheeler

Karen

David Julian Hirsh

Barton

Arthur Holden

Piano Player

Maurizio Terrazzano

Tom

Rachelle Lefevre

Holly

Erika Rosenbaum

Merry

Victoria Sanchez

Young Mother

Scott Faulconbridge

Man in Front Row

Budd Mishkin

NY1 Reporter

Carmen Echeverria

Young Girl

Gianpaolo Venuta

Young Guy

Nicholas Haze

Waiter

Ruth Chiang

Nurse Woo

Jennifer Seguin

Young Woman

Lindsay Owen Pierre

Friend

David Schaap

Man with Head Injury

Lynne Adams

Head ER Nurse

Kathleen Mackey

Heather

Gabriella Palminteri

Girl in Red Coat

Isabelle Champeau

Party Guest (uncredited)

Lucinda Davis

Nurse Gomez (uncredited)

Francesco Giannini

Family member (uncredited)

Dante Palminteri

Boy in Hospital (uncredited)

Adrianne Richards

Nurse Kline (uncredited)

Derek Schnobb

Boy (uncredited)