大泉洋

Professor Layton (voice)

堀北真希

Luke Triton (voice)

相武紗季

Emmy Altava (voice)

水樹奈々

Janice Quatlane (voice)

渡部篤郎

Jean Descole (voice)

大塚芳忠

Inspector Clamp Grosky (voice)

家弓家正

Oswald Whistler (voice)

折笠富美子

Melina Whistler (voice)

井上喜久子

Celia Raidley (voice)

諸星すみれ

Nina (voice)

飯塚昭三

Curtis O'Donnell (voice)

三宅健太

Marco Brock (voice)

豊口めぐみ

Amelia Ruth (voice)

中田譲治

Frederick Bargland (voice)

LiLiCo

Annie Dretche (voice)

山寺宏一

Pierre Starbuck (voice)

稲葉実

Don Paolo (voice)

斎藤志郎

Inspector Chelmey (voice)

能登麻美子

Flora Reinhold (voice)

納谷六朗

Dr. Andrew Schrader (voice)