Sarah Silverman

Self

Nathan Barnatt

Homeless Man (segment "Lisa")

Lauren Lapkus

Girl 5 (segment "Lisa")

John C. Reilly

Father (segment "Ham")

Laura Silverman

Self (segment "Knickers")

Seth Rogen

Officer Durand (segment "Knickers")

Jade Catta-Preta

Mother (segment "Lisa")

Natasha Leggero

Girl 2 (segment "Lisa")

Nathan Fielder

Self (segment "Retro Video Arcade")

Kyle Dunnigan

Self

Michael Daniel Cassady

Self (segment "Lisa")

Brett Gelman

Self

Emily Maya Mills

Girl 6 (segment "Lisa")

Nick Rutherford

Father (segment "Lisa")

Rob Schrab

Self

Paul Rust

Self (segment "Lisa")

Armen Weitzman

Mailman

Kulap Vilaysack

Girl 3 (segment "Lisa")

Eric Wareheim

Self

Charlyne Yi

Self

Tig Notaro

Girl 4 (segment "Lisa")

Todd Glass

Self

Grace Helbig

Bride 5 (segment "Absorption")

2 Chainz

Self (segment "Absorption")

Casey Ford Alexander

Bad Guy 2 (segment "CCDF")

Greg Davis Jr.

Groom 2 (segment "Absorption")

Trevor Eyster

Bad Guy 1 (segment "CCDF")

Kate Freund

Prostitute (segment "CCDF")

Hannah Hart

Bride 4 (segment "Absorption")

Keegan-Michael Key

Self (segment "Absorption")

Rasika Mathur

Bride 3 (segment "Absorption")

Kyle Pacek

Son (segment "Ham")

Sandeep Parikh

Groom 3 (segment "Absorption")

Jordan Peele

Self (segment "Absorption")

Issa Rae

Bride 2 (segment "Absorption")

Willy Roberts

Taco Truck Worker (segment "CCDF")

Mark Taormino

Band Member 2 (segment "Absorption")

Jack Vale

Groom 1 (segment "Absorption")