Ed Helms

Rusty Griswold

Christina Applegate

Debbie Griswold

Skyler Gisondo

James Griswold

Steele Stebbins

Kevin Griswold

Chris Hemsworth

Stone Crandall

Leslie Mann

Audrey Griswold

Chevy Chase

Clark Griswold

Beverly D'Angelo

Ellen Griswold

Charlie Day

Chad

Catherine Missal

Adena

Ron Livingston

Ethan

Norman Reedus

Trucker

Keegan-Michael Key

Jack Peterson

Regina Hall

Nancy Peterson

Emyri Crutchfield

Sheila Peterson

Alkoya Brunson

Gary Peterson

Nick Kroll

Colorado Cop

Tim Heidecker

Utah Cop

Kaitlin Olson

Arizona Cop

Michael Peña

New Mexico Cop

Hannah Jeter

Ferrari Girl

David Clennon

Harry Co-Pilot

Colin Hanks

Jake

Kirstin Ford

Mom on Plane

Ethan Maher

Boy on Plane

Elizabeth Gillies

Heather

Ryan Cartwright

Terry

Valerie Payton

Shuttle Driver

Miles Doleac

Man on the Monument

R.F. Daley

Furious Husband

Michael H. Cole

Male Guest

Brooke Jaye Taylor

Female Guest

Matthew Cornwell

Male Guest #2

John Francis Daley

Ride Operator

Libby Blake

Boobs (uncredited)

Cameron McIntyre

Young James (age 7 / 9) (uncredited)

Jonathan Goldstein

Hot Tub Guy (uncredited)

John C. McGinley

Motorbike Cop