Dennis Quaid

Lt. Tuck Pendleton

Martin Short

Jack Putter

Meg Ryan

Lydia Maxwell

Kevin McCarthy

Victor Eugene Scrimshaw

Fiona Lewis

Dr. Margaret Canker

Vernon Wells

Mr. Igoe

Robert Picardo

The Cowboy

Dick Miller

Cab Driver

Wendy Schaal

Wendy

Harold Sylvester

Pete Blanchard

William Schallert

Dr. Greenbush

Henry Gibson

Mr. Wormwood

John Hora

Ozzie Wexler

Mark L. Taylor

Dr. Niles

Orson Bean

Lydia's Editor

Kevin Hooks

Duane

Kathleen Freeman

Dream Lady

Archie Hahn

Messenger

Kenneth Tobey

Man in Restroom

Joe Flaherty

Waiting Room Patient

Andrea Martin

Waiting Room Patient

Christine Avila

Lab Technician

Jenny Gago

Lab Technician

Grainger Hines

Rusty

Richard McGonagle

Cop

Terence McGovern

Travel Agent

Rance Howard

Supermarket Customer

Chuck Jones

Supermarket Customer

Alan Blumenfeld

Man with Camera

Jeffrey Boam

Lydia's Interviewee

Paul Barselou

Man on Plane

Herb Mitchell

Camera Store Clerk

Neil Ross

Pod Computer (voice)

Robert Gray

Lab Assault Henchman

Joe Dante

Vectorscope Employee (uncredited)