Danny Trejo

Machete

Michelle Rodriguez

Luz

Jessica Alba

Sartana Rivera

Robert De Niro

Senator John McLaughlin

Steven Seagal

Rogelio Torrez

Cheech Marin

Padre Cortez

Lindsay Lohan

April Booth

Electra Avellan

Nurse Mona

Elise Avellan

Nurse Lisa

Tom Savini

Osiris Amanpour

Don Johnson

Von Jackson

Billy Blair

Von's Henchman

Jeff Fahey

Michael Booth

Shea Whigham

Sniper

Daryl Sabara

Julio

Tito Larriva

Culebra Cruzado

Alicia Rachel Marek

June

Stacy Keach

Doc Franklin

James Parks

Edgar McGraw

Ara Celi

Reporter

Mayra Leal

Chica (Naked Girl)

Juan Gabriel Pareja

Rico

Roland Ruiz

Luis

Nina Leon

Machete's Wife

Jason Douglas

Patrolman #1

Mitchell Lance Adams

Patrolman 2

Vic Trevino

Federale Officer

Jim Henry

Guard

Nimród Antal

Booth's Bodyguard #1

Chris Warner

Hospital Security Guard

Cheryl Chin

Torrez's Henchwoman

Dimitrius Pulido

Bodyguard #3

Edgar Arreola

Dishwasher