Melissa McCarthy

Tammy

Susan Sarandon

Pearl

Kathy Bates

Lenore

Mark Duplass

Bobby

Gary Cole

Earl

Allison Janney

Deb

Dan Aykroyd

Don

Sandra Oh

Susanne

Nat Faxon

Greg

Toni Collette

Missi

Ben Falcone

Keith Morgan

Sarah Baker

Becky

Rich Williams

Larry

Steve Little

Jet Ski Rental Guy

Mark L. Young

Jesse

Mia Rose Frampton

Karen

Keith Welborn

DJ

Oscar Gale

Javier

Justin Smith

Paramedic

Zach Hanner

Man at Blue Post Bar-B-Que

Jason Vail

Man at Blue Post Bar-B-Que

Leon Lamar

Old Man with Walker

Larry Dorf

Officer Mannis

Ricky Muse

Officer Curtis

Barbara Weetman

Officer Carty

William Flaman

La Grange Bail Cop

Rey Hernandez

Cop at Lakehouse

Damon Jones

Jerry Miller

J.R. Rodriguez

Kentucky Trooper (uncredited)

Michelle Rivera Huckaby

Arresting Cop (uncredited)

David Andrew Nash

Morningside Guard (uncredited)