Freddie Prinze Jr.

Pi (voice)

Rob Schneider

Nerissa (voice)

Evan Rachel Wood

Cordelia (voice)

Donal Logue

Troy (voice)

Andy Dick

Dylan / Curious Shark (voice)

Fran Drescher

Pearl (voice)

John Rhys-Davies

Thorton (voice)

R. Lee Ermey

Jack (voice)

Dylan Cash

Young Percy (voice)

Bruno Alexander

Pi's Dad (voice)

Jimmy Bennett

Young Pi (voice)

Megahn Perry

Percy's Mum / Female Parrotfish (voice)

Mel Rodriguez

Manny / Dr. Tang (voice)

Richard Epcar

Moe (voice)

Trent Ford

Percy (voice)

Kirk Zipfel

Mussel No. 1 / Squid No. 1 (voice)