Eddie Murphy

Sherman Klump / Buddy Love / Granny Klump / Mama Klump / Papa Klump / Young Papa Klump / Ernie Klump / Lance Perkins

Janet Jackson

Denise

Larry Miller

Dean Richmond

John Ales

Jason

Richard Gant

Denise's Father

Anna Maria Horsford

Denise's Mother

Melinda McGraw

Leanne Guilford

Jamal Mixon

Ernie Klump, Jr.

Chris Elliott

Restaurant Manager

Earl Boen

Dr. Knoll

Nikki Cox

Bright Student

Wanda Sykes

Chantal

Charles Walker

Preacher

Enya Flack

Bridesmaid

Kym Whitley

Party Guest

Julia Schultz

Receptionist

Barry W. Blaustein

Man in Bathroom

David Sheffield

Man in Bathroom

Bill Applebaum

Boardroom Member

Harry S. Murphy

Boardroom Member

Tom Jourden

Guy in Elevator

Kelly Konno

Dancer

Nadine Ellis

Dancer

Viola Kates Stimpson

Sweet Old Lady with Dog

Justin Urich

Lecture Student

Sonya Eddy

Heavyset Woman

Charles Napier

Four Star General

Steve Kehela

Scientist

Miguel A. Núñez Jr.

Scientist

Richard Saxton

Newscaster

Peter Segal

Scared Popcorn Man

Nikki Segal

Scared Little Girl

Kathleen Freeman

Denise's Nosy Neighbor (uncredited)