John Travolta

James Ubriacco

Kirstie Alley

Mollie Ubriacco

Olympia Dukakis

Rosie

Lysette Anthony

Samantha

David Gallagher

Mikey Ubriacco

Tabitha Lupien

Julie Ubriacco

Danny DeVito

Rocks (voice)

Diane Keaton

Daphne (voice)

George Segal

Albert

Charles Barkley

Himself

John Stocker

Sol

Elizabeth Leslie

Ruthie

Vanessa Morley

Kid at Schoolyard

Sheila Paterson

Old Waitress

Mark Acheson

Burly Dad

Ron Gabriel

Seedy Santa

Frank C. Turner

Dave

Serge Houde

Maitre D'

Roger Cross

Pilot

Michael Ryan

Pilot

Philip Maurice Hayes

Pilot

Miriam Smith

Tipsy Secretary

Robert Wisden

Ranger

J. B. Bivens

Ranger

Tegan Moss

Girl with Puppy

Chilton Crane

Girl's Mommy

Gina Chiarelli

Young Rosie

Andrew Airlie

Co-Pilot

Andrea Nemeth

Babysitter

Campbell Lane

Mollie's Dad

Bob Bergen

Dog / Wolf (voice)

Nick Jameson

Dog / Wolf (voice)

Patrick Pinney

Dog / Wolf (voice)

Rodney Saulsberry

Dog / Wolf (voice)

Nick Conti

Coach (uncredited)

Brent Sheppard

Ranger (uncredited)