Lance Crouther

Pootie Tang

JB Smoove

Trucky

Jennifer Coolidge

Ireenie

Reg E. Cathey

Dirty Dee

Robert Vaughn

Dick Lecter

Wanda Sykes

Biggie Shorty

Chris Rock

JB / Radio DJ / Pootie's Father

Mario Joyner

Lacey

Cathy Trien

Stacy

Dave Attell

Frank

Laura Kightlinger

Anchor Woman

Christopher Wynkoop

Sheriff

Rick Shapiro

Shakey

J.D. Williams

Froggy

Cole Hawkins

Little Pootie

Andy Richter

Record Executive

Kristen Bell

Record Executive's Daughter

Robert Trumbull

Board Director

David Cross

Dennis

Chuck Jeffreys

Bad Bitty

Jodi Michelle Pynn

Dirty Dee Girl

Alem Brhan Sapp

Guitar Player

Todd Barry

Greasy

Keesha Sharp

Party Girl

Jon Glaser

Recording Engineer (as John Glaser)

William Stephenson

Fast Food Cook

Robin Montague

Screaming Woman

Missy Elliott

Diva

Bryan Hearne

Little Trucky

Ebony Jo-Ann

Pootie's Mother

Bob Costas

Bob Costas

Conan O'Brien

Conan O’Brien (uncredited)

Brian Donahue

Pootie Impostor (uncredited)

Michael Broughton

Bad Bitty Goon

David S. Lomax

Dirty Dee Goon

Lanette Ware

Flashback Woman (uncredited)

Brian Smyj

Pootie Impersonator (uncredited)

Diandra Newlin

Pork Chunks Girl (uncredited)

Cecelia Antoinette

Party Girl (uncredited)