Marlon Brando

Dr. Moreau

Val Kilmer

Montgomery

David Thewlis

Douglas

Fairuza Balk

Aissa

Temuera Morrison

Azazello

Mark Dacascos

Lo-Mai

Ron Perlman

Sayer of the Law

Marco Hofschneider

M'Ling

Clare Grant

Fox Lady

William Hootkins

Kiril

Ron Vreeken

Soldier #1

Morgan Smallbone

Dog Man (uncredited)

Richard Stanley

Melting Bulldog (uncredited)

Frank Welker

Assassimon (voice) (uncredited)