Chevy Chase

Clark Griswold

Beverly D'Angelo

Ellen Griswold

Juliette Lewis

Audrey Griswold

Johnny Galecki

Russell 'Rusty' Griswold

John Randolph

Clark, Sr.

Diane Ladd

Nora

E.G. Marshall

Art

Doris Roberts

Francis

Randy Quaid

Cousin Eddie

Miriam Flynn

Cousin Catherine

Ellen Hamilton Latzen

Ruby Sue

William Hickey

Uncle Lewis

Mae Questel

Aunt Bethany

Sam McMurray

Bill

Nicholas Guest

Todd Chester

Julia Louis-Dreyfus

Margo Chester

Nicolette Scorsese

Mary

Keith MacKechnie

Delivery Boy

Brian Doyle-Murray

Frank Shirley

Natalija Nogulich

Helen Shirley

Tony Epper

Bozo #1

Alexander Folk

SWAT Officer

Jeremy Roberts

Cop