Robert Downey Jr.

Peter Highman

Zach Galifianakis

Ethan Tremblay

Michelle Monaghan

Sarah Highman

Jamie Foxx

Darryl

Juliette Lewis

Heidi

Danny McBride

Lonnie

RZA

Airport Screener

Matt Walsh

TSA Agent

Brody Stevens

Limo Driver

Todd Phillips

Barry

Bobby Tisdale

Carl

Sharon Conley

Airport X-Ray

Nathalie Fay

Flight Attendant

Emily Wagner

Flight Attendant

Steven M. Gagnon

Air Marshall

Paul Renteria

Border Guard

Marco Rodríguez

Federali Agent

Mimi Kennedy

Sarah's Mom

Tymberlee Hill

New Mother

Keegan-Michael Key

New Father

Aaron Lustig

Dr. Greene

Charlie Sheen

Charlie Harper

Jon Cryer

Alan Harper

Jeremy Ambler

TSA Agent (uncredited)

Madeline Brumby

Airport Pedestrian (uncredited)

Sarah Reagin Clemmensen

Airport Security Agent (uncredited)

Connie Sawyer

Elderly Airport Passenger (uncredited)